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Pharmacokinetics (PK) Pharmacodynamics (PD) Studies in Drug Discovery and Development

Event ID :- 1766 CE
Event Type :- Webinar
Date :- May 02 - 04, 2022
Venue :- Online
Organised by :- Webinar Compliance

Pharmacokinetics (PK) describes the time course of drugs in the organism i.e. the processes that a drug undergoes after administration. PK, therefore, assesses the absorption, distribution, metabolism, and excretion of new chemical entities. In other words, what the body does to the drug.

PK/PD is essential in drug discovery for target validation, optimization of lead compounds development, and compounds scaling to humans.

Why You Should Attend:

To get a better understanding of how pharmacokinetics (PK) and pharmacodynamics (PD) are correlated and how these correlations can streamline the drug discovery and development programs.

Investigation of the PK/PD correlations is extremely valuable during early drug discovery to fully interpret the pharmacological data in preclinical disease models and the safety signals observed during toxicological studies including the evaluation of the safety margins.

During drug development, investigation of PK/PD correlations will support dose selection for clinical trials, target patient population and endpoint selection, comparison with competitors, and will help during the interpretation of drug safety and tolerability.

The webinar will describe the basic concepts of PK/PD in drug discovery and development by reviewing drug exposure measurements, plasma protein binding, biomarkers, exposure-effect relationships.

The webinar will examine the importance of dosing schedules and target engagement and problems in evaluating time-response relationships.

You will understand how PK/PD adds significant value to study design in both the pre- and clinical setting and how this can increase the chance of success in drug discovery and development.

Areas Covered in the Session :





Case study

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